Pompe disease has 2 main types, Infantile (IOPD) and Late Onset (LOPD)
Infantile Onset: Usually it is diagnosed as soon as the infants motor skills become apparent. Symptoms of classic infantile-onset Pompe disease commonly begin at around 4 months of age. They include poor feeding due to muscle weakness in the face and tongue, leading to slow growth (failure to thrive). Other symptoms include muscle weakness and delayed motor development, difficulty breathing and respiratory infections, and heart problems. Hearing loss is also common in babies with classic infantile-onset Pompe disease.
Late Onset Pompe Disease (LOPD): Late onset (including juvenile onset) Pompe disease may not become apparent until later in childhood, adolescence, or adulthood. Late-onset Pompe disease is usually milder than the infantile-onset forms of this disorder and is less likely to involve the heart. Most individuals with late-onset Pompe disease experience progressive muscle weakness, especially in the legs and the trunk, including the muscles that control breathing. As the disorder progresses, breathing problems can lead to respiratory failure. The primary symptom is muscle weakness progressing to respiratory weakness.
